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Pathophysiology of metformin associated lactic acidosis

Modernizr=function(a,b,c){function C(a)function D(a,b)function E(a,b)function F(a,b)function G(a,b)function H(a,b,d)function I(a,b,c)function J(),s.svg=function(),s.inlinesvg=function();for(var K in s)B(s, K)&&(x=Lower Case(),e[x]=s[K](),v.push((e[x]? In order to use Medscape, your browser must be set to accept cookies delivered by the Medscape site. Metformin is frequently used alone or in combination to treat type 2 diabetes.

Pathophysiology of metformin associated lactic acidosis

Pathophysiology of metformin associated lactic acidosis

Metformin is an oral hypoglycemic drug that has long been employed in the treatment of type 2 diabetes; it is particularly widely prescribed for those diabetics who are obese. Very rarely, metformin use results in severe lactic acidosis, most often occurring in patients with reduced renal function.

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  • Metformin, a dimethylbuanide, is a widely used oral antihyperglycaemic drug used in the long term treatment of type 2 diabetes mellitus.


    Pathophysiology of metformin associated lactic acidosis

    Pathophysiology of metformin associated lactic acidosis

    Pathophysiology of metformin associated lactic acidosis

    The UK Prospective Diabetes Study, a large clinical trial performed in 1980-90s, provided evidence that metformin reduced the rate of adverse cardiovascular outcomes in overweht patients with type 2 diabetes relative to other antihyperglycemic agents. Moleno DO, MS (EM Resident Physician, UTSW/Parkland Memorial Hospital) and Asey Haynes MD (Toxicology Fellow, UTSW/Parkland Memorial Hospital) // Edited by: Alex Koyfman MD (@EMHh AK) and Stephen Alerhand MD (@SAlerhand) A 43 year-old woman with a past medical history of depression, DM, and HTN presents to the Emergency Department 2.5 hours after a suicide attempt by prescription drug ingestion.

    Pathophysiology of metformin associated lactic acidosis

    Metformin is a first-line agent for type 2 diabetes mellitus often used as monotherapy or in combination with oral diabetic medications. ASPIRIN AND SOMA


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